International Journal of Natural Products and Marine Biology
Year Of Started:      2015 Published By:   SBT JOURNALS
Frequency:   Quarterly ISSN:                2455-2755

Anti Diabetic Activity of aerial parts of Glinus oppositifolius L, against glucose overloaded and streptozotocin induced Diabetes in Albino Rats.

Suman Pattanayak , K. Padmalatha

In the scrutiny of alleged antidiabetic potential, effect of the petroleum ether, chlorororm and methanol, extracts of Glinus oppositifoliuson fasting blood sugar levels and serum biochemical analysis in streptozotocin-induced diabetic rats were investigated. Among the all the threeextracts, the methanolic extract 500 mg/kg orally, was produce significantly reduce blood glucose level at normal, glucose over loaded normal rats, and streptozotocin induced diabetic rats after 15 days treatment ;whereas petroleum ether and chloroform extract 500 mg/kg orally, did not exhibit any significant effect on three groups of rats. Concurrent histological studies of the pancreas of these animals showed comparable regeneration by methanolic extract which were earlier, necrosedby streptozotocin. The results showed that it has significant hypoglycemic effect in experimental model of diabetes mellitus. The antidiabetic activity of methanolic extract may be due to the presence of steroids, saponinglycosides, alkaloids and flavonoids.

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